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This central action modulates appetite-regulating neurons, leading to reduced food intake and increased satiety
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Among the patients who develop NASH, 10–20% will progress to higher-grade fibrosis and approximately 5% will develop overt cirrhosis (1) ( Figure 1 Triglycerides (TG) accumulation is likely one of the first steps in the pathophysiology of NAFLD as a result of an impaired free fatty acid (FFA) metabolism in the liver (Figure 2)